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acinetobacter baumannii treatment

Clin. Successful treatment of skin and soft tissue infection due to carbapenem-resistant Acinetobacter baumannii by ampicillin-sulbactam and meropenem combination therapy. doi: 10.1128/AAC.01672-09, Lee, Y. T., Tsao, S. M., and Hsueh, P. R. (2013). 51, 2211–2214. J. Antimicrob. Infect. OmpA is also related with resistance to aztreonam, chloramphenicol, and nalidixic acid (Smani et al., 2014). doi: 10.1093/jac/dkl004, Principe, L., Capone, A., Mazzarelli, A., D'Arezzo, S., Bordi, E., Di Caro, A., et al. Antimicrobial activity of Gallium Protoporphyrin IX against Acinetobacter baumannii strains displaying different antibiotic resistance phenotypes. Cell 152, 884–894. Antimicrob. The potent activity of BV100 against CRAB, the novel formulation, novel mode of action and the potential for an abbreviated path to approval represents a very attractive opportunity to develop this urgently needed medicine for patients in need. Antimicrob. Med. This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply. Antimicrobial resistance of Acinetobacter spp. Antimicrob. Acinetobacter baumannii outer membrane protein A targets the nucleus and induces cytotoxicity. by PCR. 64, 222–227. (2012). A urinary tract Enterococcus faecalis isolate that apparently requires vancomycin to grow was reported in 1994, and this phenomenon is called “antimicrobial agent dependence.” Colistin dependence was reported in an A. baumannii–A. BV100 has completed GLP toxicology studies and has shown outstanding in vitro and in vivo efficacy in several animal models, with unprecedented in vitro strain coverage against CRAB and a very low propensity to develop resistance. [Epub ahead of print]. 82, 4200–4208. Clin. (2016). These results indicate that blocking LPS synthesis is a powerful strategy for discovering novel antibiotics. World J. Clin. J. Antimicrob. Antimicrob. Single amino acid substitution Gly186Val in AdeS restores tigecycline susceptibility of Acinetobacter baumannii. Bhuiyan, M. S., Ellett, F., Murray, G. L., Kostoulias, X., Cerqueira, G. M., Schulze, K. E., et al. Serum resistance of the surA1 mutant significantly decreases compared with that of the wild-type strain CCGGD201101. Beyond OmpA, the A. baumannii envelope is associated with many factors that contribute to pathogenicity. doi: 10.1093/jac/dkw382, Sheng, W. H., Wang, J. T., Li, S. Y., Lin, Y. C., Cheng, A., Chen, Y. C., et al. In addition, the presence of antibiotics induces hyperproduction of capsular polysaccharides (Geisinger and Isberg, 2015). J. Bacteriol. Agents Chemother. Microb. The innate immune metal-chelating protein calprotectin inhibits bacterial growth by host-mediated chelation of metals, such as zinc (Zn2+ and Zn) and manganese (Mn2+ and Mn) (Corbin et al., 2008). Similarly, minocycline therapy in combination with colistin is effective to treat infections caused by minocycline-resistant A. baumannii. Diagn. (2008). J. Bacteriol. Therefore, the cipA mutant strain is efficiently killed by human serum and also shows a defect in the penetration of endothelial monolayers (Koenigs et al., 2016). Antimicrob. Agents Chemother. Diagn. Microbiol. Pathog. Medically relevant Acinetobacter species require a type II secretion system and specific membrane-associated chaperones for the export of multiple substrates and full virulence. 61:e01309–16. Another β-lactamase inhibitor tazobactam increases the activity of peptide antibiotics, such as colistin and daptomycin, in a murine model of A. baumannii pneumonia (Sakoulas et al., 2016). doi: 10.1093/jac/dkw355, Lenhard, J. R., Gall, J. S., Bulitta, J. Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production. doi: 10.1371/journal.pone.0062160, Kim, C. K., Lee, Y., Lee, H., Woo, G. J., Song, W., Kim, M. N., et al. 89, 816–830. In some European ICUs, we see that Acinetobacter baumannii infections are even resistant to colistin, the last resort medicine, and thus, we are left with no further treatment options. 48, 612–614. Biofilm formation in Acinetobacter baumannii: associated features and clinical implications. J. Antimicrob. 186, 126–138. 37, 747–748. 52, 1613–1617. Agents 48, 331–336. Agents Chemother. J. Antimicrob. 58, 1806–1808. Eur. Development of colistin-dependent Acinetobacter baumannii-Acinetobacter calcoaceticus complex.

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